Parkinson’s disease symptoms: One early sign to look out for when you go to the toilet

Parkinson’s disease doesn’t cut your life short, but it can lead to increased disability and poor health. What’s an early sign of the condition you can spot in the toilet? Charity Parkinson’s Foundation explains that the disease predominantly affects the dopamine-producing neurons in a specific area of the brain called substantia nigra. There are typical patterns of progression in Parkinson’s […]

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Preclinical study offers hope for Hirschsprung’s disease

Babies with Hirschsprung’s disease are born with an incomplete or absent gut nervous system. Children’s Hospital Los Angeles investigator Tracy Grikscheit, MD, runs a laboratory that investigates the therapeutic potential of tissue engineering—the induced growth of healthy tissue using stem cells. In a new study, Dr. Grikscheit successfully grew a fully functional gut nervous system—or ENS—in a pre-clinical model. While […]

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Yale New Haven Health rapidly deploys remote monitoring for ventilator patients

Earlier this year, in New Haven, Connecticut, the location of Yale New Haven Health’s main hospital, the health system was challenged by how many COVID-19 patients would need to be admitted and ventilated. THE PROBLEM The health system wanted to ensure its respiratory therapists and other clinicians could continue to deliver high-quality care amid a surge of patients. The concern, […]

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Probing innate immunity, cGAS protein, and our own damaged DNA

The protein cGAS plays an essential role in cellular innate immunity by detecting the DNA of invading pathogens such as bacteria and viruses, or our own damaged and mislocalized DNA. Activation of the cGAS-STING signaling pathway produces a pro-inflammatory immune response, and prolonged activation of cGAS can result in lupus-like autoimmune disorders. Manuel Ascano, Ph.D., and colleagues previously identified the […]

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Live Science podcast ‘Life’s Little Mysteries’ special report: Coronavirus (May 21)

In this special episode of Life’s Little Mysteries, we focus on a serious topic that everybody is talking about: SARS-CoV-2, and the disease it causes, COVID-19. Every day at Live Science, our reporters and editors track the latest coronavirus developments around the world: from global case numbers and quarantines, to vaccine development, to best practices for safety, prevention and treatment. […]

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