Researchers leading a worldwide clinical trial aimed at finding treatments for Alzheimer’s disease are modifying an arm of the trial to evaluate a combination of drugs targeting two brain proteins: amyloid and tau. The trial – known as the Tau Next Generation Trial (Tau NexGen) – originally was announced with a focus on drugs that target tau, but with increasing […]
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A new study led by researchers at Washington University School of Medicine in St. Louis suggests that a widely used heart failure drug named sacubitril/valsartan is no better than valsartan alone in patients with severe heart failure. The study also provides evidence that the treatment with valsartan may be slightly safer for patients with advanced heart failure. The study was […]
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause inflammatory lung disease, including clot formation and hyper-permeability of the lung vessels, resulting in edema and bleeding into the lung. Inflammation also affects other organs, mediated by the cytokine storm. This inflammation is characterized by endothelial cell dysfunction in multiple organs. The cause of this endothelialopathy is unknown. It could […]
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Negative emotional states and physical pain are intimately connected. Numerous people who suffer from chronic, persistent pain also deal with negative emotions and loss of motivation. Some even become clinically depressed eventually, and doctors sometimes prescribe antidepressants to treat chronic pain, even though the pathways that link pain and mood are poorly understood. Now, studying the brains and behavior of […]
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The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of millions of people over the world, with more than 4.5 million deaths. The most striking part of the outbreak is the fact that a majority of those infected show mild or no symptoms, while a significant minority develop severe or critical disease. Several studies have explored the immunological responses to […]
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The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS–COV-2) virus in Wuhan, China, in 2019 and the subsequent coronavirus disease 2019 (COVID-19) pandemic has been linked to the anthropogenic biodiversity crisis and climate change. History of COVID-19. The disturbance or destruction of the natural environment through human activity has resulted in a loss of biodiversity. Consequent to these […]
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A new episode of our podcast, “Show Me the Science,” has been posted. At present, these podcast episodes are highlighting research and patient care on the Washington University Medical Campus as our scientists and clinicians confront the COVID-19 pandemic. Recently, the federal government decided that vaccine booster shots will be made available for Americans 65 and older, those with compromised […]
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Air pollution is an established environmental hazard. It is known to be linked to both respiratory disease and that of the heart and vascular system. However, recently its association with Alzheimer's disease (AD) has been suspected and explored in many studies. Image Credit: Melinda Nagy/Shutterstock.com There are six primary types of air pollutants, including ozone (O3), particulate matter (PM), carbon […]
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The use of plastic is one of the conveniences of modern life, but in recent years microplastic contamination has become an emerging global concern. Microplastics ––plastic particles measuring less than 5mm ––are everywhere ––from the deepest oceans to the air we breathe. Their small size and mass mean they are readily transported by wind and microplastics have been found in […]
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Thank you so much for reaching out about this. We are so sorry to hear about your loss. It sounds like you are worried about the feelings you are having around the loss of your mom. Losses can be incredibly hard and it is normal and natural for anyone to experience the feelings you are having. Grief is how we […]
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