Childhood Eczema and Mental Health: Where is the Link?

By Keynote ContributorDr. Carine ParentResearch Project Coordinator
Ludmer Centre for Neuroinformatics & Mental Health

The link between eczema in childhood and mental health problems in later life has been the subject of research for many years. The evidence was recently compounded by a large, population-based study that found a strong association between eczema and attention-deficit/hyperactivity disorder (ADHD), anxiety and depression, amongst others.

Credit: Taborsky/

The prevalence of allergic diseases has increased in the past few decades, especially within highly developed countries. Atopic dermatitis (AD) or eczema is a cutaneous allergy and the most common chronic medical condition in children[1]. Eczema is characterized by an inflammatory rash associated with excessive itching and scratching[2].

This medical condition is associated with significant health care costs and reduces the quality of life of affected children and their families[3]. The disease is most common in young children and becomes less common with increasing age[2].


Since the early 1900’s studies have shown a link between eczema and other allergies and mental health problems[4,5].  More recently, several European studies have shown that children with eczema have an increased prevalence of psychological and behavioral problems or mental health disorders[6,7,8].

These findings have been confirmed in a large population-based study in the United States. In particular, eczema is associated with an increased risk for attention-deficit/hyperactivity disorder (ADHD), conduct disorder, autism, anxiety and depression[9].

The influence of gender

While the association between eczema and mental health disorders has been established, the role of gender in this association has not been fully examined. Some studies have found higher rates of anxiety and depression in females with eczema than in males[10,11,5]. These studies were conducted in adulthood though and the role of sex in influencing the association between eczema and risk for mental illness has not been extensively studied in young children.

Recently, we used data collected from the Maternal Adversity, Vulnerability, and Neurodevelopment (MAVAN) community study to determine if boys and girls with early life cutaneous allergies including eczema have greater emotional and behavioral problems in childhood. We recruited 630 mothers and their babies for the study, which was carried out in Montreal and Hamilton, Canada.

In the MAVAN community study, we found that girls with early childhood cutaneous allergies including eczema were at greater risk for mental health issues later on in life than girls without childhood cutaneous allergies. However, this was not true for boys, who had similar rates of emotional and behavioral problems with or without cutaneous allergies in early childhood[12].

Several studies emphasize a greater risk for psychological and behavioral problems in adult females with eczema. For example, women with hand eczema show greater impairments in mental health-related quality of life compared to men with eczema[13].

Adult female patients with eczema were also found to have greater anxiety and depression compared to male patients with eczema[10,5,11].  Meanwhile asthma, hay fever or eczema in mid-adolescence associated with greater internalizing problems in late adolescent girls only[7].

Females show a greater immune response than males and this leads to an increased prevalence of autoimmune diseases in females compared to males[15]. The greater severity of allergic symptoms noted in young girls compared to boys may be due to both sex-based differences and due to the less studied immunomodulatory role of gender in eczema disease predisposition and severity[16].

Hormonal and genetic differences due to the presence of two X chromosomes in girls may predispose girls to greater immune responses and possibly greater symptoms due to eczema. Disease severity in girls may also be greater because of greater environmental exposure to allergens and skin irritants in girls than boys and differences in the recognition and treatment of the disease in girls compared to boys.

Cytokines and physiological stress

Eczema is caused by inappropriate immune activation and  the release of higher levels of inflammatory proteins called cytokines. It is thought that this physiological process may be mediating the association between eczema and mental health.

Cytokines are known to affect the functioning of brain regions that influence emotions and behavior and important interactions exist between sex hormones and cytokines[17].

Psychological stress exacerbates eczema symptoms and may even trigger the development of eczema skin rashes[4]. There are differences in how males and females react to emotional stress. Further, stress can induce sensitization of cytokines in brain regions that regulate emotions and behavior.

Girls with eczema may have greater brain pro-inflammatory cytokine levels or cytokine sensitization than boys with eczema. This, in turn, may predispose girls with eczema to greater behavioral disturbances such as increased conduct problems compared to boys with eczema.

It was previously shown that asthma in early childhood precedes the development of internalizing behaviors in adolescence inferring a potential causal relationship between allergy and mental health disturbances[20]. Health care practitioners should then be made aware of the increased vulnerability for mental health problems in young girls with childhood eczema in order to plan effective treatment interventions in this potentially at-risk population.

Credit: Designua/

About Dr. Carine Parent

Carine Parent, Ph.D. completed undergraduate studies in biology and psychology at McGill University. Dr. Parent completed doctoral graduate training in neuroscience at McGill University in 2014. She is currently a neuroscientist at the Douglas Mental Health University Institute, an institution affiliated with McGill University in Montreal, Canada.

She studies how early life stress increases the risk for mental health disorders using both animal models and human cohorts. Part of her research focus is on how early life stress, infectious burden in early life and components of the immune system including cytokines can be used to predict the risk for mental health disorders in later life.



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2. Lyons JJ, Milner JD, Stone KD (2015) Atopic dermatitis in children: clinical features, pathophysiology, and treatment. Immunol Allergy Clin North Am 35(1):161-83

3. Ben-Gashir MA, Seed PT, Hay RJ (2004) Quality of life and disease severity are correlated in children with atopic dermatitis. Br J Dermatol 150(2):284-90

4. Koo J, Lebwohl A (2001) Psycho dermatology: the mind and skin connection. Am Fam Physician 64(11):1873-8

5. Timonen M, Jokelainen J, Hakko H, Silvennoinen-Kassinen S, Meyer-Rochow VB, Herva A, Räsänen P (2003) Atopy and depression: results from the Northern Finland 1966 Birth Cohort Study. Mol Psychiatry 8(8):738-44

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11. Amorim-Gaudêncio CR, G, Sirgo A (2004) Evaluation of anxiety in chronic dermatoses: Differences between sexes. Interam J Psychol 38:105-14

12. Parent C, Pokhvisneva I, Gaudreau H, Diorio J, Meaney MJ, Silveira PP (2018) Community study found that cutaneous allergies in childhood were associated with conduct problems in girls. Acta Paediatr. Epub ahead of print.

13. Wallenhammar LM, Nyfjäll M, Lindberg M, Meding B (2004) Health-related quality of life and hand eczema–a comparison of two instruments, including factor analysis. J Invest Dermatol 122(6):1381-9

14. Lien L, Green K, Thoresen M, Bjertness E (2010) Atopic conditions and mental health problems: a 3-year follow-up study. Eur Child Adolesc Psychiatry 19(9):705-13

15. Oertelt-Prigione S (2012) The influence of sex and gender on the immune response. Autoimmun Rev 11(6-7):A479-85

16. Gerada E, Agius-Muscat H, Camilleri L, Montefort S (2015) Gender differences in the prevalence and severity of wheezing, allergic rhinitis and eczema in 5-8 year old and 12-15 year old Maltese children (ISAAC-Malta). European Respiratory Journal 46:1337

17. Elenkov IJ, Chrousos GP (2002) Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann N Y Acad Sci 966:290-303

18. Chaplin TM, Hong K, Bergquist K, Sinha R (2008) Gender differences in response to emotional stress: an assessment across subjective, behavioral, and physiological domains and relations to alcohol craving. Alcohol Clin Exp Res 32(7):1242-50

19. Dantzer R (2005) Somatization: a psychoneuroimmune perspective. Psychoneuroendocrinology 30(10):947-52

20. Alati R, O'Callaghan M, Najman JM, Williams GM, Bor W, Lawlor DA (2005) Asthma and internalizing behavior problems in adolescence: a longitudinal study. Psychosom Med 67(3):462-70

Further Reading

  • All Eczema Content
  • What is Eczema?
  • Eczema Types
  • Eczema Treatment
  • Eczema Research

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Last Updated: Jan 29, 2021

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