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<img class="aligncenter" src="https://scx1.b-cdn.net/csz/news/800a/2023/researchers-target-com.jpg"
alt="Researchers target commonly mutated or deleted gene in gynecological cancers"
title="FBXW7 isoforms and SCF-FBXW7 complex. (A) Three FBXW7 isoforms (α, β, and γ), which are structurally different only at their N-terminal region, while sharing conserved domains in the C-terminal region. Each of these isoforms consists of three domains: dimerization domain (DD), sotalol 120 mg bula F-box domain, and tandem WD40 repeats. (B) The SCF-FBXW7 complex in FBXW7 dimerization format for substrate ubiquitylation. Credit: Cells (2023). DOI: 10.3390/cells12101415″ width=”800″ height=”477″>
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