Brain area thought to impart consciousness, behaves instead like an Internet router: The brains claustrum, receives, amplifies, and broadcasts an Internet network required to complete complex cognitive tasks

Tucked underneath the brain’s outer, wrinkly cortex is a deeply mysterious area, known as the claustrum. This region has long been known to exchange signals with much of the cortex, which is responsible for higher reasoning and complex thought. Because of the claustrum’s extensive connections, the legendary scientist Francis Crick, PhD, of DNA-discovery fame, first postulated in 2005 that the claustrum is the seat of consciousness. In other words, the region of the brain enabling awareness of the world and ourselves.

Researchers at the University of Maryland School of Medicine, however, now posit that Crick may have been incorrect: They developed a new theory — built on data — that the claustrum behaves more like a high-speed internet router, taking in executive commands from “boss” areas of the brain’s cortex that forms complex thoughts to generate “networks” in the cortex. Acting like a router, the claustrum coordinates these networks to work together to accomplish the many different cognitively demanding tasks we perform on a moment-to-moment basis in everyday life.

Understanding how the brain forms and coordinates these networks in the cortex through the claustrum is important, since disorganized networks are a typical feature across many disorders, such as addiction, Alzheimer’s disease, and schizophrenia. This insight may help lead to better therapies to address cognitive dysfunction in these disorders.

“The brain is the most complex system in the known universe. It is these data-driven theoretical advances that propel our knowledge forward toward harnessing that complexity for improving human life,”said Brian Mathur, PhD, Associate Professor of Pharmacology at UMSOM. “As the most highly connected structure in the brain, the claustrum is a window into the enigma of the brain, the mind.”

Their new findings and hypothesis were published on Sept. 30, 2022, in Trends In Cognitive Sciences.

In an effort to identify the precise role of the claustrum, Dr. Mathur and his colleagues conducted a serious of experiments on both animals and people. One experiment used modern neuroscience approaches to turn off the claustrum in conscious mice. These mice didn’t lose consciousness and kept running around normally. One strike against Crick’s theory!

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