New mouse model mimics human pathology of childhood restrictive cardiomyopathy

Severe childhood restrictive cardiomyopathy is a condition that causes the muscles in the walls of the heart to become stiff, so that the heart is unable to fill properly with blood. A mutation in a protein called BAG3 is known to result in restrictive cardiomyopathy, muscle weakness, difficulty taking in enough oxygen, and damage to multiple peripheral nerves, often shortening […]

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Scientists are deciphering the details of immune cell activation

Chemokine receptors, located at the surface of many immune cells, play an important role in cell function. Chemokines are small proteins that bind to these receptors and control the movement and behavior of white blood cells. However, despite the importance of this family of receptors, their activation mechanism remains poorly understood. In Switzerland, a research consortium from the University of […]

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Secukinumab Provides Clinical Benefit for JIA Subtypes

Secukinumab (Cosentyx), an interleukin-17A inhibitor, is effective and reasonably well tolerated for treatment of enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) in children and adolescents, according to a phase 3 trial presented at a late breaking abstracts session of the annual European Congress of Rheumatology. On the primary outcome of time to flare, the curves for secukinumab and placebo […]

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ONC releases draft of address standardization specification

The U.S. Office of the National Coordinator for Health Information Technology has partnered with standards development organizations and other experts to release the Project US@ Draft Technical Specification Version 1.0 for public comment. The draft specification is aimed at standardizing patient addresses across healthcare to improve patient matching, which in turn supports safety, privacy and security, care coordination and interoperability. […]

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Recibir la ayuda de FEMA para funerales de covid requiere tenacidad… y ayuda

Jessica Rodríguez, directora de la funeraria Ingold Funeral and Cremation en Fontana, California, ayuda a las familias a despedirse de sus seres queridos. “Servimos sobre todo a familias latinas, la mayoría de ellas de segunda y tercera generación”, dijo Rodríguez. “Pero también tenemos bastantes que son de primera generación, y no hablan nada de inglés”. Rodríguez dijo que la mayoría […]

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The vision: Tailored optical stimulation for the blind

Stimulation of the nervous system with neurotechnology has opened up new avenues for treating human disorders, such as prosthetic arms and legs that restore the sense of touch in amputees, prosthetic fingertips that provide detailed sensory feedback with varying touch resolution, and intraneural stimulation to help the blind by giving sensations of sight. Scientists in a European collaboration have shown […]

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Here’s Why Straight Women Might Prefer Lesbian Porn, According To Sex Therapists

People love lesbian porn—especially women. In fact, the term “lesbian” was the most searched term among women on Pornhub in 2019 and the most searched term in the United States overall. (Though it’s worth noting that Pornhub isn’t the most historically ethical site.) It’s all fine and good that lesbian porn is getting online hype, but consider this: While lesbian […]

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