Midlife Change in Wealth May Be Costly for Heart Health

Midlife changes in wealth may affect a patient’s risk of cardiovascular disease, a new cohort study suggests. It found that upward wealth mobility relative to peers was independently associated with protection against cardiovascular disease after age 65. In contrast, downward wealth mobility during middle age was linked to an increased risk of adverse cardiovascular events. Dr Muthiah Vaduganathan “A lot […]

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What underlies inconsistent clinical trials results for COVID-19 drugs?

A new modeling study suggests that significant variation in virus dynamics from person to person may be a contributing factor to inconsistent findings reported in clinical trials for antiviral COVID-19 drugs. Recruiting trial participants shortly after symptoms begin could reduce the number of participants required to detect significant antiviral drug effects, according to Shoya Iwanami and Shingo Iwami of Nagoya […]

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Lipidomics research provides clues for drug resistance in schizophrenia

Researchers from Skoltech and the Mental Health Research Center have found 22 lipids in the blood plasma of people with schizophrenia that were associated with lower symptom improvement over time during treatment. These can help track resistance to medication that affects over a third of patients. The paper was published in the journal Biomolecules. Studies suggest that up to 34% […]

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Study shows how loss of de-N-glycosylation enzyme causes ill effect

Cytosolic peptide:N-glycanase (NGLY1) is a widely conserved enzyme involved in de–N-glycosylation of N-glycosylated proteins. Mutations in the human NGLY1 gene cause global developmental delay and multisystemic symptoms, but the molecular mechanism underlying pathogenesis remains poorly understood. Loss-of-mutations in NGLY1, an enzyme that removes sugar chains, cause a multisystem developmental disorder called NGLY1 deficiency. Researchers from Tokyo Metropolitan Institute of Medical […]

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Study explores the effects of SARS-CoV-2 (and other betacoronaviruses) on cellular mRNA processing

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic and has been identified as the third human coronavirus outbreak of the 21st century. Though predominantly a respiratory virus, SARS-CoV-2 can affect multiple organs, including the kidneys, the heart and the brain. The extent of the disease severity is also extremely […]

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Sleep deprivation increases teen angst

Sleep deprivation—from lifestyle choices, pandemic stress, or late-night computer study—can quickly lead to loss of energy and function during the day and even feelings of anger and depression, an Australian sleep institute study has shown. The study, led by Flinders University, asked 34 healthy teenagers (20 males) aged between 15 and 17 to spent 10 days and nine nights in […]

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