Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

In a recent study published in the journal PLOS One, researchers present the crystal structure of an anti-non-structural protein 9 (nsp) specific nanobody in complex with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nsp9, which they termed nsp9COV19. Study: Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9. Image Credit: Kateryna Kon / Shutterstock.com Background Nsp9 is a small […]

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How Old Is Too Old to Start Strength Training?

Aging may be the greatest threat to your freedom and independence you’ll ever know, only because of what it does to your muscles. “The anabolic hormones that are responsible for maintaining muscle decline with age,” says Brandon Grubbs, PhD, assistant professor of exercise physiology and co-leader of the Positive Aging Consortium at Middle Tennessee State University. “Older adults also tend […]

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Clinical, technical and environmental biases influencing equitable access to clinical genetics and genomics testing

With the goal of fostering awareness and identifying strategies to reduce bias within the medical genetics field and to improve health equity, members of the ACMG’s Social, Ethical and Legal Issues (SELI) and Diversity, Equity and Inclusion (DEI) Committees collaborated to address factors in which bias can occur in clinical genetic testing in a just-published statement, “Clinical, technical, and environmental […]

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Colorectal cancer in the mother linked to adverse pregnancy outcomes

In a nationwide Swedish study of 207 births to women with an earlier diagnosis of colorectal cancer (CRC), researchers found an increased risk of both maternal and neonatal adverse outcomes. The study was published in eClinicalMedicine and is a collaboration between Washington University in St Louis and Karolinska Institutet. Early-onset colorectal cancer (diagnosed before age 50) has risen worldwide, resulting […]

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Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

In a recent study published in the Cell journal, researchers showed how a dietary tryptophan (Trp) metabolite synthesized by the probiotic Lactobacillus reuteri (Lr) invaded the gut-distal tumor microenvironment (TME) of melanoma patients and facilitated their immune checkpoint inhibitor (ICI) treatment. Study: Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment. Image Credit: Kateryna Kon/Shutterstock.com Introduction In this way, they evidenced […]

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Targeted diets and probiotics can modulate gut microbiota to combat obesity

In a recent study published in the Nutrients Journal, researchers explored the regulation of gut microbiota via a two-phase and low-calorie diet among obese persons. Study: Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals Image Credit: sdecoret/Shuttertsock.com Background The gut microbiota (GM) involves a complex microbial community of fungi, bacteria, parasites, and viruses that exist symbiotically in the human gastrointestinal […]

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