How chandelier cells light up the brain

Within the intricate network of cells that make up the brain, chandelier cells stand out for their elaborate, branching structure. With an elegant shape similar to that of its namesake, a single chandelier cell reaches out to connect and communicate with more than 100 other neurons. Abnormalities in chandelier cells have been linked to epilepsy, autism, and schizophrenia, underscoring their […]

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What’s the difference between asymptomatic and presymptomatic spread of coronavirus?

With evolving updates from the World Health Organization and the Centers for Disease Control and Prevention in Atlanta about the novel coronavirus, there may be some confusion about the ways it can spread. There is a difference between asymptomatic and presymptomatic spread of the virus, which causes the disease COVID-19. Here’s a breakdown of the differences and some questions people […]

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Creating a new paradigm for understanding the individual effects of diet

Researchers at the Australian National Phenome Centre at Murdoch University and partners at Imperial College London have made a major breakthrough in understanding how individuals can have different reactions to the same diets. For decades, nutritionists and scientists have been debating whether weight loss is down to sheer will power and healthiness of diet, or whether maintaining a healthy weight […]

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Open-source machine learning tool connects drug targets with adverse reactions

A multi-institutional group of researchers led by Harvard Medical School and the Novartis Institutes for BioMedical Research has created an open-source machine learning tool that identifies proteins associated with drug side effects. The work, published June 18 in the Lancet journal EBioMedicine, offers a new method for developing safer medicines by identifying potential adverse reactions before drug candidates reach human […]

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Without intervention, a 70% reduction in strokes or death in patients with brain AVMs

For people with a brain arteriovenous malformation, a congenital vascular system defect, fate has a name: stroke. To avoid this risk, patients sometimes undergo interventions to remove the malformation. But is this very beneficial? Not necessarily. According to an international clinical trial, co-directed by researchers from the University of Montreal Hospital Research Centre (CRCHUM), interventional treatment—by neurosurgery, neuroradiology or radiation […]

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Here’s what doctors know about immunizations right now: You still need them

There’s no vaccine for COVID-19 yet. But there are routine immunizations that people aren’t getting for a host of debilitating and potentially deadly diseases. In May, the Centers for Disease Control and Prevention reported sharp drop-offs beginning in mid-March for pediatric vaccines ordered and given. And the World Health Organization estimated up to 80 million babies globally were missing recommended […]

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WHO halts COVID-19 hydroxychloroquine trials

The World Health Organization said it had decided Wednesday to halt trials of hydroxychloroquine as a potential treatment for COVID-19 patients, finding it did not reduce the mortality rate. Doctor Ana Maria Henao Restrepo, from the WHO’s health emergencies programme, told a virtual press conference in Geneva that the antimalarial drug was being withdrawn from its multi-country Solidarity Trial of […]

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