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In a new study, researchers including Yale School of Medicine’s Michael Simons, MD, identify the molecular underpinnings of persistent endothelial-to-mesenchymal transition (EndMT), an important process related to vascular inflammation in diseases including pulmonary hypertension.

Researchers found atypical acetate production from glucose triggered metabolic modulation of the endothelium activated TGF-β signaling, is renovation allowed on saturday triggering a positive feedback loop and EndMT persistence.

The work identifies endothelial ACSS2 as a potential therapeutic target for reducing atherosclerosis. The study is published in the journal Cell Metabolism.

More information:
Xiaolong Zhu et al, Acetate controls endothelial-to-mesenchymal transition, Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.05.010

Journal information:
Cell Metabolism

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