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John Lydon discusses his wife's battle with dementia on GMB

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Ageing populations are understood to be driving up dementia rates, but no plan has yet proven successful in curbing these trends. Though it’s been established that a healthy lifestyle can lower the likelihood of the disease, sharper measures will be needed to make a significant difference in the coming years. Evidence is mounting that drugs to treat arthritis fare well in the prevention of cognitive decline due to their anti-inflammatory agents.

In 2019, research published in the journal of Neurotherapeutics established that people with rheumatoid arthritis (RA) treated with standard medications had less than half the risk of developing dementia over a five-year period compared to people without RA.

The study of more than 20,7000 patients determined that disease-modifying anti-rheumatic drugs successfully reduced inflammation and slowed the progression of RA.

But further observations made during the study suggested the drugs also reduced the risk of developing dementia.

In fact, the drug’s effects appeared to further decrease this risk at high cumulative dosages.

These findings were replicated in a 2021 study, which also found dementia rates declined among patients with RA, while it increased among the overall population.

The most convincing findings to date, phentermine heart pain however, have probably emerged from the latest study published in the Seminars on Arthritis and Rheumatism.

Results suggest that people diagnosed with RA, taking the newest and most effective treatments, developed the condition 19 percent less often over three years compared to those treated with older treatments.

Harvard Health notes that together, the studies “suggest […] certain treatments that help RA might do more than protect the joints; they might also protect the brain”.

It continues: “This isn’t the first time medicine was found to cause an important unexpectedly positive side effect. But it could be one of the most important.”

While the evidence is growing that inflammation-suppressing medicines could play a protective role against dementia, more research is needed.

Most of the studies conducted to date have used an observational methodology, meaning they’re unable to prove a causative relationship.

Further research, however, could elucidate the clinical relevance of arthritic medicines for preventing dementia.

Understanding how the drugs work might also shed light on the latest scientific findings.

Inflammation is a key feature of rheumatoid arthritis, a feature which is also believed to play a major role in the onset of dementia.

The anti-inflammatory role of some foods and drugs has previously been explored for their lowering effect on the risk of dementia.

Elizabeth Klingbeil, PhD, registered dietitian and assistant professor in the department of Nutrition & Dietetics at Johnson & Wales University-Providence, told Healthline that inflammation plays an important role in dementia.

She said: “The role of inflammation in neuro-cognition diseases – such as dementia – has been well-established.

“Thereby, decreasing the amount of systemic inflammation in the body may reduce the risk of development or severity of these diseases.”

Combined with regular activity and stress reduction, a diet rich in anti-inflammatory foods may reduce the risk of cognitive decline.

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