Steroid may cut death risks for covid patients more than other drugs
Cheap steroid dexamethasone lowers the risk of death by 36% for COVID-19 patients on ventilators – but hydroxychloroquine does little to help those with mild infections, studies reveal
- A new University of Oxford study found that the steroid dexamethasone – which costs about $50 a treatment course – reduces death risks
- Effects are most notable for ventilated patients, who face 36% lower odds of death with the drug
- Three new studies found hydroxychloroquine, the malaria drug touted by Trump does little to treat coronavirus even if given early
With additional research, the cheap steroid, dexamethasone, continues to show promise for treating coronavirus, while the likelihood that hydroxychloroquine can help patients dwindles.
A University of Oxford study found that, for patients so ill that they need to be on ventilators, dexamethasone can cut the risk of death by more than a third.
Hydroxychloroquine did not perform so well in its most recent tests. The same Oxford study found that the malaria drug favored by President Trump did little for severely ill COVID-19 patients.
Studies from Spain and the University of Minnesota found it did not offer much benefit to people with milder infections, either.
The mad scramble to find a treatment that might save the lives of people with coronavirus has resulted in a flurry of trials that raised and dashed hopes, but at last it’s becoming clearer which drugs might help to stem the mounting coronavirus death toll.
FILE – This Tuesday, June 16, 2020 file photo shows a bottle and box for dexamethasone in a pharmacy in Omaha, Neb. On Friday, July 17, 2020, British researchers published a report on the only drug shown to improve survival — the inexpensive steroid dexamethasone. Two other studies found that the malaria drug hydroxychloroquine does not help people with only mild coronavirus symptoms. (AP Photo/Nati Harnik)
Fresh studies give more information about what treatments do or don’t work for COVID-19, with high-quality methods that give reliable results.
British researchers on Friday published their research on the only drug shown to improve survival — a cheap steroid called dexamethasone. Two other studies found that the malaria drug hydroxychloroquine does not help people with only mild symptoms.
For months before studies like these, learning what helps or harms has been undermined by ‘desperation science’ as doctors and patients tried therapies on their own or through a host of studies not strong enough to give clear answers.
‘For the field to move forward and for patients´ outcomes to improve, there will need to be fewer small or inconclusive studies’ and more like the British one, Drs. Anthony Fauci and H. Clifford Lane of the National Institutes of Health wrote in the New England Journal of Medicine.
‘It’s now time to do more studies comparing treatments and testing combinations, said Dr Peter Bach, a health policy expert at Memorial Sloan Kettering Cancer Center in New York.
Here are highlights of recent treatment developments:
DEXAMETHASONE: $50 COURSE OF STEROIDS COULD REDUCE DEATH RISKS FOR THE SICKEST PATIENTS
The British study, led by the University of Oxford, tested a type of steroid widely used to tamp down inflammation, which can become severe and prove fatal in later stages of COVID-19.
About 2,104 patients given the drug were compared to 4,321 patients getting usual care.
It reduced deaths by 36% for patients sick enough to need breathing machines: 29% on the drug died versus 41% given usual care. It curbed the risk of death by 18% for patients needing just supplemental oxygen: 23% on the drug died versus 26% of the others.
However, it seemed harmful at earlier stages or milder cases of illness: 18% of those on the drug died versus 14% of those given usual care.
The clarity of who does and does not benefit ‘probably will result in many lives saved,’ Fauci and Lane wrote.
HYDROXYCHLOROQUINE: MALARIA DRUG DID NOT IMPROVE SURVIVAL ODDS FOR SEVERELY ILL PATIENTS OR SPEED RECOVERY WHEN GIVEN EARLY
The same Oxford study also tested hydroxychloroquine in a rigorous manner and researchers previously said it did not help hospitalized patients with COVID-19.
After 28 days, about 25.7 percent on hydroxychloroquine had died versus 23.5 percent given usual care – a difference so small it could have occurred by chance.
Now, details published on a research site for scientists show that the drug may have done harm. Patients given hydroxychloroquine were less likely to leave the hospital alive within 28 days – 60 percent on the drug versus 63 percent given usual care.
Those not needing breathing machines when they started treatment also were more likely to end up on one or to die.
A trio of recent trials suggest that hydroxychloroquine, the malaria drug touted by Trump, does little to improve survival odds for severely ill coronavirus patients or to treat mildly ill patients when given early
Two other experiments found that early treatment with the drug did not help outpatients with mild COVID-19.
A study of 293 people from Spain published in the journal Clinical Infectious Diseases found no significant differences in reducing the amount of virus patients had, the risk of worsening and needing hospitalization, or the time until recovery.
A similar study by University of Minnesota doctors in Annals of Internal Medicine of 423 mildly ill COVID-19 patients found that hydroxychloroquine did not substantially reduce symptom severity and brought more side effects.
‘It is time to move on’ from treating patients with this drug, Dr. Neil Schluger from New York Medical College wrote in a commentary in the journal.
REMDESIVIR: GILEAD’S ANTIVIRAL MAY SHORTEN HOSPITAL STAYS BUT WHETHER IT CAN SAVE LIVES REMAINS UNKNOWN
The only other therapy that’s been shown to help COVID-19 patients is remdesivir, an antiviral that shortens hospitalization by about four days on average.
‘The role of remdesivir in severe COVID is now what we need to figure out,’ Memorial Sloan Kettering’s Bach wrote in an email, saying the drug needs to be tested in combination with dexamethasone now.
US government trials found remdesivir can shorten hospital stays for coronavirus patients, but it’s not yet clear how effectively it can treat severely ill patients
Details of the government-led remdesivir study have not yet been published, but researchers are eager to see how many patients received other drugs such as steroids and hydroxychloroquine.
Meanwhile, Gilead Sciences, the company that makes remdesivir, which is given as an IV now, has started testing an inhaled version that would allow it to be tried in less ill COVID-19 patients to try to keep them from getting sick enough to need hospitalization. Gilead also has started testing remdesivir in a small group of children.
Supplies are very limited, and the US government is allocating doses to hospitals through September.
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