Asthma and food allergies during childhood associated with increased risk of irritable bowel syndrome

Asthma and food hypersensitivity at age 12 is associated with an increased risk of having irritable bowel syndrome at 16, a new study presented today at UEG Week Virtual 2020 has found.

The research, conducted at the University of Gothenburg and the Karolinska Institute in Stockholm, Sweden, analyzed the health of 2,770 children from birth to the age of 16. Those with IBS at 16 were almost twice as likely to have had asthma at the age of 12 (11.2% vs 6.7%). Almost half of children with IBS at 16 (40.7%) reported food hypersensitivity at 12 years (compared to 29.2% of children without IBS at 16).

The research also showed that asthma, food hypersensitivity and eczema were all associated with an increased risk of concurrent IBS at 16 years.

The population-based cohort study was led by Dr. Jessica Sjölund from the Institute of Medicine at the University of Gothenburg, Sweden. “The associations found in this large study suggest there’s a shared pathophysiology between common allergy-related diseases and adolescent irritable bowel syndrome,” she explained. “We knew that allergy and immune dysregulation had been suggested to play a role in the development of irritable bowel syndrome, but previous studies on allergy-related diseases and irritable bowel syndrome are contradictory. This knowledge could open up for developing new treatment methods for adolescent IBS, targeting processes of low grade inflammation seen in these allergy-related diseases.”

During the study, children and parents were asked to complete questionnaires regarding asthma, allergic rhinitis, eczema and food hypersensitivity at ages 1, 2, 4, 8, 12 and 16 years. At 16, children answered questions based on the Rome III Questionnaire on Pediatric Gastrointestinal Symptoms, allowing participants to be categorized into IBS, functional abdominal pain, and function dyspepsia groups.

IBS affects more than one in ten people2 and is the most common functional gastrointestinal disorder. It can be extremely disabling for patients, with abdominal cramps, bloating, diarrhea or constipation. There are often difficulties in diagnosing functional gastrointestinal disorders like IBS, and just one in three people with symptoms of IBS or constipation consult a healthcare professional.

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