Neuronal cells cultured in the laboratory or in vitro provide a model to understand neuronal biology. Neurons derived from human pluripotent stem cells (hPSC) are a tool to study neurobiology and disease pathology and for modeling diseases. However, it is challenging to grow hPSC-derived neurons in vitro due to the lack of a suitable platform. Study: Bidirectional cell-matrix interaction dictates neuronal network formation in […]

Type 2 diabetes can be a 'devastating diagnosis' says expert We use your sign-up to provide content in ways you’ve consented to and to improve our understanding of you. This may include adverts from us and 3rd parties based on our understanding. You can unsubscribe at any time. More info Blood sugar levels that are left unmanaged can set the […]

Mental Health First Aid (MHFA) training teaches people to identify and be able to respond effectively to mental illness in others. Dedicated courses teach mental health first aid strategies to members of the public. This first aid is given until appropriate professional help is found, or the crisis abates. This article looks at the growing need for MHFA, actonel therapeutic […]

Driving up the immune response at the site of a cancer tumor with nanotechnology may help enhance immunotherapy treatments in advanced stages of the disease, new research in mice suggests. In mouse models of numerous types of cancer, scientists boosted activation of T cells, important fighters in an immune response, inside tumors in a way that improved their interactions with […]

(HealthDay)—About 44 percent of persons aged 65 years or older received a booster or additional primary dose of COVID-19 vaccine during Aug. 13 to Nov. 19, 2021, in the United States, according to research published in the Dec. 10 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report. Noting that adults ages 65 […]

<img class="aligncenter" src="https://scx1.b-cdn.net/csz/news/800a/2021/human-microrna-inhibit.jpg" alt="Human microRNA inhibits expression of pathogenic gene underlying facioscapulohumeral muscular dystrophy" title="Fig. 1: miR-675 targets the DUX4 ORF and 3′UTR. a RenLuc-DUX4-FL dual-luciferase reporter and CMV.H19 constructs, and U6.MIR675, H1.MIR675, U6.MIR675-3p, and U6.MIR675-5p miRNAs. RenLuc-DUX4-FL contains DUX4 ORF and 3′UTR sequences fused to Renilla luciferase after the stop codon. Exons 1–3 are indicated (Ex1,2, anafranil 10 3). […]

Almost as soon as the gravity of the coronavirus disease 2019 (COVID-19) pandemic was known, vaccine development went on apace over the next year to prevent the hundreds of thousands of deaths that would eventually be recorded as the result of this outbreak. The approval of the first few vaccines was followed by their widespread deployment in developed countries and […]

INTEGRA Biosciences provides an extensive range of multichannel and electronic pipettes – as well as robotic-assisted platforms – to help increase the throughput of your cell culture workflows. Switching to electronic pipettes or automated systems has been proven to offer significant advantages over manual processes, providing reproducible results with fewer handling errors, while eliminating the painstaking work of repetitive liquid […]

<img class="aligncenter" src="https://scx1.b-cdn.net/csz/news/800a/2021/distinct-differences-e.jpg" alt="Distinct differences exist between sense of smell distortions associated with COVID-19" title="Word cloud of nouns used to describe triggers of parosmia, with size representing word frequency across 375 parosmics. Credit: Robert Pellegrino, PhD, prozac skutki uboczne Monell Chemical Senses Center” width=”800″ height=”405″> Sudden smell and taste loss has become a well-known symptom of COVID-19. However, some people […]

ATLANTA — Patients with acute myeloid leukemia (AML) bearing mutations in isocitrate dehydrogenase 1 (IDH1) who could not withstand the rigors of intensive therapy had improved event-free and overall survival when they were treated with the combination of ivosidenib (Tibsovo) and azacitidine (Onureg, Vidaza) compared with azacitidine alone. The results come from the phase 3 AGILE trial. The ivosidenib-azacitadine (IVO-AZA) […]