A perplexing range of neurodegenerative diseases are known to attack distinct regions of the brain, causing severe cognitive and motor deficit. The combined impact of these (generally fatal) diseases has inflicted a devastating toll on society. New insights suggest many of these afflictions have their origin in a constellation of common processes, which play out in different ways as each […]

A recent draft released by the World Health Organization explained the new global strategy to address the gaps in infection prevention and control (IPC) programs that became apparent after the coronavirus disease 2019 (COVID-19) pandemic. The draft also highlighted strategies to ease the burden of multidrug-resistant microbial infections in a healthcare setting. Source: Draft global strategy on infection prevention and control. […]

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London and the University of Surrey has found that working from home may have impacted health behaviors and well-being during the COVID-19 lockdown of spring 2020. The study, published in the Journal of Occupational and Environmental Medicine, explored people’s experiences of working from home during the […]

European public health authorities have met a formidable opponent in the race to end the AIDS epidemic by 2030: late HIV.  At last count, slightly more than half of diagnoses in European Union (EU)/European Economic Area (EEA) countries were associated with a CD4 cell count <350 cells/mm3, 35% of which were considered advanced (ie, presenting for care with an AIDS-defining […]

A Northwestern Medicine study has discovered that elevated PALI1 in advanced prostate tumors mediates crosstalk between two primary epigenetic silencing mechanisms, suggesting that dual epigenetic inhibition may be an effective therapeutic strategy, according to findings published in Molecular Cell. “Our discoveries of PALI1’s critical role in bridging and exploiting two major epigenetic silencing machineries for gene repression and tumor promotion […]

Dr. Tracy Wilson, a Nurse Practioner based in Houston, Texas, terazosin blurred vision began her journey into the healthcare field when she was as young as 8 years old. “When I was 8 years old, my mom had to have a hysterectomy,” she says. “She needed someone to clean her wound and so I became her little mini nurse.” Flash […]

An analysis of more than 100,000 colorectal cancer cases and 154,000 healthy controls published in Nature Genetics uncovered hundreds of signals that may serve as new treatment and prevention targets. This study is twice as large as previous genome-wide association studies, according to the paper. The collaboration included researchers affiliated with hundreds of studies and institutions across Europe, North America […]

The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in the coronavirus disease 2019 (COVID-19) pandemic. Although most individuals infected with SARS-CoV-2 are asymptomatic or experience mild symptoms, some succumb to severe infection with chronic lung injury and acute respiratory distress syndrome (ARDS). Study: SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. […]

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers led by scientists from the DKFZ-Hector Cancer Institute at the University Medical Center Mannheim and the University Medical Center Hamburg Eppendorf has now identified an enzyme that controls the activity of osteoblasts. An agent that inhibits the activity of this enzyme reduced […]

Dementia affects over 55 million people worldwide, and cases are expected to rise in the next decade due to an aging global population. Obesity, often measured using body mass index (BMI), coumadin center is a widespread epidemic that’s been linked to an increased risk of dementia — but the relationship between BMI and dementia risk is not fully understood. In […]