Hard to drug: Protein droplets reveal new ways to inhibit transcription factors in an aggressive form of prostate cancer

Transcription factors play essential roles in turning the genetic information encoded in genes into proteins in all cells and organisms. These regulatory proteins bind DNA, turn genes on or off, and control the rate at which DNA is transcribed into mRNA, which is needed for protein synthesis. Because of their central role in transcriptional control, many diseases can be traced […]

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South Floridas HIV dilemma: How to prevent babies from being born with the disease

As the international community observes World AIDS Day on Friday, doctors in South Florida confront a challenging reality: More women locally are getting HIV. A percentage of those women will become pregnant and give birth to babies who are infected. “We know how to prevent HIV in babies,” said Dr. Lisa-Gaye Robinson, HIV medical director and principal investigator for clinical […]

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CN Bio PhysioMimix Organ-on-a-Chip data supports Inipharm’s INI-822 for metabolic liver disease treatment now in clinical testing

CN Bio, a leading Organ-on-a-Chip (OOC) company that designs and manufactures single-and multi-organ microphysiological systems (MPS), today announced its PhysioMimix® assay for Non-alcoholic steatohepatitis (NASH) was important for confirmation of efficacy for INI-822 from Inipharm, a biopharmaceutical company focused on discovering and developing therapies for severe liver diseases. The use of in vitro OOC for early evidence of efficacy for […]

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New adaptive clinical trial aims to reverse neurological damage caused by progressive multiple sclerosis

Reviewed The first-ever adaptive clinical trial for Australians living with MS will seek to reverse neurological damage caused by progressive multiple sclerosis. With an initial $4 million in funding, the trial, commencing in January 2024, will enable researchers to investigate the potential benefits of several medications simultaneously, giving hope to the cohort of people living with one of the most […]

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