Women with rheumatoid arthritis have bone fragility

(HealthDay)—Premenopausal women with long-standing rheumatoid arthritis (RA) have systemic bone fragility at peripheral sites, according to a study published online Aug. 30 in Arthritis & Rheumatology. Mariana O. Perez, M.D., Ph.D., from Universidade de Sao Paulo in Brazil, and colleagues explored the relationship between parameters of systemic and localized bone involvement in 80 consecutive premenopausal women with long-standing RA (median, […]

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Pancreatic cancer ‘priming’ may make chemotherapy more effective

A new approach to ‘prime’ the tumor environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer. In preclinical models, a team at the Garvan Institute of Medical Research could enhance the tumors’ response to chemotherapy by reducing the stiffness and density of the connective tissue known as the stroma, […]

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How infection by SARS-CoV-2 can lead to kidney disorders

A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo (UNIFESP) in Brazil discusses the mechanisms whereby SARS-CoV-2 damages the kidneys, potentially serving as a basis for further research in pursuit of treatments to prevent severe renal problems and even chronic kidney disease in COVID-19 patients. The study shows that interaction with angiotensin-converting enzyme […]

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More than one third of COVID-19 patients diagnosed with at least one long-COVID symptom

Thirty-seven percent of people had at least one long-COVID symptom diagnosed in the 3–6 month period after COVID-19 infection. The most common symptoms were breathing problems, abdominal symptoms, fatigue, pain and anxiety/depression. This new study from the University of Oxford and the National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre (BRC) investigated long-COVID in over 270,000 people […]

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Sanofi Ditches mRNA COVID-19 Vaccine After Rivals’ Success

PARIS (Reuters) – Sanofi is dropping plans for its own mRNA-based COVID-19 vaccine because of the dominance achieved by BioNTech-Pfizer and Moderna in using the technology to fight the pandemic, the company said on Tuesday. The move highlights the challenges of competing in particular with pioneer BioNTech, which rose from obscurity through its alliance with pharma major Pfizer last year. […]

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Alzheimer’s Drug Targets People With Mild Cognitive Impairment. What Does That Mean?

The approval of a controversial new drug for Alzheimer’s disease, Aduhelm, is shining a spotlight on mild cognitive impairment — problems with memory, attention, language or other cognitive tasks that exceed changes expected with normal aging. After initially indicating that Aduhelm could be prescribed to anyone with dementia, the Food and Drug Administration now specifies that the prescription drug be […]

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