New Malaria Drug Candidate Passes First-in-Human Test

NEW YORK (Reuters Health) – ZY19489, a novel triaminopyrimidine antimalarial compound, has successfully passed a first-in-human clinical trial, demonstrating promising safety, pharmacokinetics and antimalarial activity, according to a new report. Conducted in 48 healthy adult volunteers in Australia, the study showed ZY-19489 was well tolerated up to the maximum dose tested of 1,500 mg, Dr. Bridget Barber with QIMR Berghofer […]

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Study: Worlds vulnerable are being polluted in their own homes as they cook

The first-of-its-kind study found that poor ventilation and fuel choices were the most significant contributors to poor air quality in people’s kitchens, but the size of the kitchen and the way food was cooked also mattered. Frying food led to particularly high levels of indoor pollution. Professor Prashant Kumar, Founding Director of the University of Surrey’s Global Centre for Clean […]

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Women with one ovary less likely to have a successful IVF outcome, study shows

Women who have had one ovary surgically removed (unilateral oophorectomy) are less likely to become pregnant after in vitro fertilization and give birth to fewer babies than women with both ovaries. That is according to an extensive meta-analysis published in the journal Fertility and Sterility by researchers at Karolinska Institutet in Sweden. Whether women's fertility is affected by the removal […]

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Survey: People turned to gardening for stress relief, food access during pandemic

People who turned to gardening during the COVID-19 pandemic did so to relieve stress, connect with others and grow their own food in hopes of avoiding the virus, according to a survey conducted by researchers at the University of California, Davis, UC Agriculture and Natural Resources (UCANR) and international partners. The survey report, “Gardening during COVID-19: Experiences from gardeners around […]

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Vaccine effectiveness wanes after three months among care home residents

Vaccination-acquired immunity against COVID-19 wanes substantially after three months among elderly care home residents, suggesting that regular booster jabs may be needed for this group, according to preliminary findings from the Vivaldi study led by UCL researchers. The study, funded by the UK Health Security Agency and published on the preprint site medRxiv, looked at data from over 15,000 residents […]

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‘Zapping’ air passages may bring relief for severe asthma

Inhalers, pills or injections help most people control their asthma, but some with severe disease opt for cutting-edge surgery that “remodels” their airways to improve their breathing. Bronchial thermoplasty shrinks smooth muscle in the lungs, which prevents them from tightening up and causing an attack. The U.S. Food and Drug Administration approved the treatment for adults with severe asthma in […]

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