ACE2 decoy receptor with robust neutralization against Omicron subvariants shows therapeutic potential

Researchers in the United States have shown the inhalation of an angiotensin-converting enzyme 2 (ACE2) decoy receptor, sACE22.v2.4-IgG1, increases survival and ameliorates lung injury in K18-hACE2 transgenic mice infected with a lethal dose of the virulent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gamma variant. Moreover, the engineered decoy binds tightly to spike (S) of BA.1 and BA.2 omicron, despite […]

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Genetically determined levels of inflammation linked to neuropsychiatric illness

A potential link between inflammation and the structure of specific regions of the brain has been identified by researchers at the University of Birmingham. The study, published today in JAMA Psychiatry, may be particularly relevant for neurodevelopmental psychiatric disorders including autism spectrum and schizophrenia. Researchers say the findings could open up a completely new target for the pharmacological treatment of […]

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FDA Okays New Med for Lennox-Gastaut Syndrome

The US Food and Drug Administration (FDA) has approved fenfluramine (Fintepla) oral solution, a Schedule IV controlled substance, for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in children aged 2 years and older, the company has announced. As reported by Medscape Medical News, fenfluramine is already approved in the US to treat seizures associated with Dravet syndrome. LGS […]

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Hay fever could feel worse during the night – expert explains why and how to overcome it

GMB: Ranvir Singh suffering from hay fever concerning Richard We use your sign-up to provide content in ways you’ve consented to and to improve our understanding of you. This may include adverts from us and 3rd parties based on our understanding. You can unsubscribe at any time. More info Nasal congestion is often worse at night, pathologist Heather Wright confirmed. […]

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A bioinformatics approach for detecting SARS-CoV-2 co-infections

In a recent study published on the medRxiv* preprint server, researchers discuss a novel bioinformatics-based method for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infections with the Delta and Omicron variants. Study: Detection and prevalence of SARS-CoV-2 co-infections during the Omicron variant circulation, France, December 2021 – February 2022. Image Credit: NIAID  Background To date, five SARS-CoV-2 variants […]

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