CD1 lipidomes exhibit size-based antigen display mechanisms

In a recent study published in the journal Cell, researchers identify lipidomes as four cluster of differentiation 1 (CD1) antigen-presenting molecules and, as a result, reveal a map of self-lipid display. Study: CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms. Image Credit: Crevis / Shutterstock.com T-cell responses Understanding T-cell response is informed by the interaction of its receptor (TCR) with peptide […]

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Study finds wrist temperature linked with future risk of disease

Continuous wrist temperature monitoring can uncover insights into the potential for future disease risk for ailments like type 2 diabetes, hypertension, liver disease, kidney failure, and more. These new findings from Perelman School of Medicine researchers, recently published in “Nature Communications,” shows that accurate, continued digital monitoring of skin temperature can give deeper medical insights. Previously, disrupted temperature rhythms had […]

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Rewiring tumor mitochondria enhances the immune systems ability to recognize and fight cancer

Immunotherapy, which uses the body’s own immune system to fight cancer, is an effective treatment option, yet many patients do not respond to it. Thus, cancer researchers are seeking new ways to optimize immunotherapy so that it is more effective for more people. Now, Salk Institute scientists have found that manipulating an early step in energy production in mitochondria—the cell’s […]

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Which Factors Predict Primary Nonadherence to Medications?

Poor adherence to medication is a real challenge in healthcare. Despite evidence indicating therapeutic benefit from adhering to a prescribed regimen, it is estimated that around 50% of patients around the world don’t take their medication as it is prescribed — and some simply don’t take them at all. Nonadherence to medication can be primary or secondary. Primary medication nonadherence […]

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Pain Evaluated as Pyoderma Gangrenosum Outcome Measure

TOPLINE: A 2-point improvement in pain based on a numeric rating scale may indicate that patients are responding to treatment for pyoderma gangrenosum. METHODOLOGY: To help determine whether a patient with pyoderma gangrenosum is responding to treatment, researchers used a patient global assessment (PGA) score to establish a minimal important difference (MID) in the measure of pain. The MID was […]

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DPP4 inhibitors for target therapy resistance in renal cell carcinoma

A new editorial paper titled “Potential repurposing of DPP4 inhibitors for target therapy resistance in renal cell carcinoma” has been published in Oncotarget. In their new editorial, researchers Kuniko Horie and Satoshi Inoue from Saitama Medical University and Tokyo Metropolitan Institute for Geriatrics and Gerontology discuss renal cell carcinoma (RCC)—a major adult kidney cancer, which is often incidentally discovered as […]

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