Relevance of stem-loop 2 motif in SARS-CoV-2 and astroviruses

A recent paper posted to the bioRxiv* preprint server demonstrated that the stem-loop 2 motif (s2m) was substantial for astroviruses but unnecessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ​​​​​​​Study: The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2. ​​​​​​​Image Credit: NIAID Background Astroviruses are single-stranded, non-enveloped, positive-sense ribonucleic acid (RNA) viruses, […]

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Hypertonic saline solution enhances glymphatic spinal cord delivery of pharmaceutical agents

The glymphatic system enables the flow of cerebrospinal fluid to the brain tissue, particularly during sleep, enabling the fluid to cleanse the tissue and carry accumulated metabolites with it towards the bloodstream during waking hours. Previously, it has been observed that the function of the glymphatic system can be modulated with drugs. This makes it an interesting target for drug […]

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UK study suggests adolescents’ diet quality is neither healthy nor sustainable

New research being presented at this year’s European Congress on Obesity (ECO) in Maastricht, Netherlands (4-7 May), suggests secondary school pupils across the West Midlands region of the UK are not eating a healthy, sustainable diet. The study is by Dr. Ankita Gupta and colleagues from the University of Birmingham, UK. In 2019, The EAT-Lancet Commission called for a broad […]

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12 safety tips to reduce ATV injury

All-terrain vehicles (ATV) offer adventure for riders, but parents need to be aware of the dangers when children are involved. ATV injuries have skyrocketed at UC Davis Children’s Hospital over the past two years. So, pediatric trauma surgeons are sounding the alarm about the dangers of ATVs for children under 18 years of age. Injuries in children ages 6 to […]

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Physician assistants commonly employed in dermatology

Many physician assistants (PAs) are employed in dermatology, with a larger annual increase seen for PAs in dermatology versus other specialties, according to a research letter published online May 4 in JAMA Dermatology. Justin D. Arnold, M.D., from the University of California in Irvine, and colleagues characterized the dermatology PA workforce in a cross-sectional study using deidentified longitudinal data from […]

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‘Forever Chemicals’ Linked to Liver Damage

Exposure to per- and polyfluoroalkyl substances (PFAS) ― a class of widely used synthetic chemicals dubbed “forever chemicals” ― can lead to liver damage and may be a culprit in rising rates of nonalcoholic fatty liver disease (NAFLD), say the authors of a comprehensive evidence review. They found “consistent” evidence for PFAS hepatotoxicity from rodent studies. In addition, exposure to […]

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Low-cost, sensor-equipped insole to monitor gait of patients with mobility impairments

An interdisciplinary team of University of Massachusetts Amherst researchers has developed a low-cost shoe insole, equipped with force-sensitive resistors (FSR), that aims to improve the management of health conditions that impair mobility, such as stroke, Parkinson’s disease and osteoarthritis. The insole “measures two important kinetic parameters that are relevant to how people walk; that is, the ground reaction force (GRF) […]

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What to Do When Politics Make You & Your Partner Fight

The heart wants what it wants, and sometimes it turns out it wants someone with a political outlook different than yours. You might think: “If two people truly love one another, their politics won’t matter.” But for certain relationships, bickering about candidates or issues can be an unresolvable hurdle leading to some less-than-loving fights about your values — and it […]

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