Fatty liver disease susceptibility: study identifies interaction between estrogen receptor and genetic variant in women

In a recent article published in Nature Medicine, researchers pursued evidence of whether the interaction between the patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M variant and the female sex at the genetic and molecular level explains why premenopausal women remain protected against fatty liver disease (FLD) while a rapidly progressive disease ensues in some peri- and postmenopausal women. Study: Interaction between estrogen receptor-α […]

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Risk of premature birth from smoking while pregnant more than double previous estimates

Cambridge researchers have found that women who smoke during pregnancy are 2.6 times more likely to give birth prematurely compared to non-smokers—more than double the previous estimate. The study, published today in the International Journal of Epidemiology, also found that smoking meant that the baby was four times more likely to be small for its gestational age, putting it at […]

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Genetic variation with MASLD reveals subtypes and potential therapeutic avenues

An astounding 30% of Americans currently have metabolic dysfunction-associated steatotic liver disease, or MASLD, which is formerly known as nonalcoholic fatty liver disease, or NAFLD, and many are unaware that they have it. Over time, MASLD can lead to cirrhosis, liver failure and even liver cancer. The disease is also associated with and might be caused by factors that contribute […]

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LDL-Lowering Tied to Lower First CVD Events in Patients 70+

TOPLINE: Patients older than age 70 years have a 23% lower risk of a first major vascular events with each 1 mmol/L lowering of low-density lipoprotein (LDL) cholesterol, which is similar to the benefit seen among younger patients in primary prevention, new research shows. METHODOLOGY: Using various cross-linked Danish registries, researchers analyzed 65,190 participants aged 50 years and older (49,155 […]

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Researchers discover that heart cells in developing zebrafish start beating suddenly and all at once

Becoming a full-fledged organism out of a handful of cells, complete with functioning tissues and organs, is a messy yet highly synchronized process that requires cells to organize themselves in a precise manner and begin working together. This process is especially dramatic in the heart, where static cells must start beating in perfect unison. Now, a cross-school collaboration led by […]

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A Resurfaced Clip of Princess Diana Popping off With a Snarky Comeback Has Gone Viral — & We’re Applauding Her Mama Bear Instincts

An old video is making the rounds on TikTok, and though it doesn’t show the whole story, it does show that Princess Diana was always ready to stand up for her sons. In the clip, then-Prince Charles, Princess Diana, and a 6-month-old Prince William sit on a couch together. And over the video, it says “Princess Diana responds to her […]

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