A fast, highly sensitive, point-of-care RT-LAMP and CRISPR/Cas12a assay for the detection of SARS-CoV-2

In a recent study posted to the Research Square* preprint server, researchers used isothermal amplification with clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).  Study: Rapid, multiplex detection of SARS-CoV-2 using isothermal amplification coupled with CRISPR-Cas12a. Image Credit: creativeneko/Shutterstock Background To date, there have been over 546 million confirmed cases of coronavirus […]

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Casirivimab/imdevimab improve outcomes in early COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19). Since its emergence at the end of 2019, SARS-CoV-2 has infected over 550 million and caused over 6.3 million deaths globally. The rapid spread of SARS-CoV-2 significantly impacted national economies, while also causing severe disruptions to both national and international travel. In the absence of effective […]

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Diabetes Tied to Risk of Long COVID, Too

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Individuals with diabetes who experience COVID-19 are at increased risk for long COVID compared to individuals without diabetes, according to data from a literature review of seven studies. Diabetes remains a risk factor for severe COVID-19, but whether it is a risk factor for postacute sequelae […]

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Tissue model reveals key players in liver regeneration: By tracing the steps of liver regrowth, engineers hope to harness the livers regenerative abilities to help treat chronic disease

The human liver has amazing regeneration capabilities: Even if up to 70 percent of it is removed, the remaining tissue can regrow a full-sized liver within months. Taking advantage of this regenerative capability could give doctors many more options for treating chronic liver disease. MIT engineers have now taken a step toward that goal, by creating a new liver tissue […]

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Could carbon monoxide foam help fight inflammation? Foams that incorporate small amounts of the gas could be delivered to the GI tract to combat colitis and other conditions

Carbon monoxide is best known as a potentially deadly gas. However, in small doses it also has beneficial qualities: It has been shown to reduce inflammation and can help stimulate tissue regeneration. A team of researchers led by MIT, Brigham and Women’s Hospital, the University of Iowa, and Beth Israel Deaconess Medical Center has now devised a novel way to […]

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Watchdogs Attack Medicare Advantage for Denying Care and Overcharging

Congress should crack down on Medicare Advantage health plans for seniors that sometimes deny patients vital medical care while overcharging the government billions of dollars every year, government watchdogs told a House panel Tuesday. Witnesses sharply criticized the fast-growing health plans at a hearing held by the Energy and Commerce subcommittee on oversight and investigations. They cited a slew of […]

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Researchers find two FDA-approved drugs that curb symptoms of Alzheimer’s disease

Two commonly used psychiatric drugs show evidence of improving symptoms of Alzheimer’s disease including boosting cognition, according to a study from researchers at the University of Colorado Anschutz Medical Campus. “The people who received these drugs developed better cognition and actually improved in their clinical diagnosis,” said the study’s senior author Huntington Potter, Ph.D., professor of neurology at the University […]

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New machine learning technique shows how drugs can be repurposed

A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers. Through information from the three-dimensional (3D) structure of genomes and epigenetics—how genes and environment jointly influence diseases—the investigators were able to identify genes associated with complex traits and […]

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