Microbial metabolites as risk factors for Parkinsons disease

A research team has discovered a microbial metabolite that destroys dopamine-producing neurons. Further experiments showed that Parkinson-like symptoms occur as a result. This research, led by Thomas Böttcher from the Institute of Biological Chemistry and the Center for Microbiology and Environmental Systems Science (CeMESS) at the University of Vienna and Marcel Leist from the University of Konstanz, in collaboration with […]

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Fragile X syndrome may be unfolding in brain cells even before birth

Reviewed Fragile X syndrome, the most common form of inherited intellectual disability, may be unfolding in brain cells even before birth, despite typically going undiagnosed until age 3 or later. A new study published today in the journal Neuron by researchers at the University of Wisconsin–Madison showed that FMRP, a protein deficient in individuals with fragile X syndrome, has a […]

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Stopping the cycle of recurrent urinary tract infections in women

A study by UT Southwestern Medical Center researchers is the first to demonstrate the long-term efficacy of electrofulguration, a minimally invasive outpatient procedure that treats chronic urinary tract infections (UTIs) among postmenopausal women. Researchers reviewed the medical records of 96 women treated at UT Southwestern for recurrent UTIs (three or more a year) with electrofulguration between 2006 and 2012. Telephone […]

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Scientists identify new pathway activated by interferon-gamma that leads to tumor cell death

Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new role for a protein called extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that can trigger cells to self-destruct. Researchers found that interferon-gamma signaling caused hyperactivation of ERK in human melanoma cell lines. The ERK protein, when hyperactive, causes stress in the cell, and this stress […]

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New Covid variant identified in Northern Ireland – key symptoms to spot

GMB: Professor Susan Hopkins asked about symptoms of Covid The new coronavirus variant has been detected in Northern Ireland, according to health officials. Dubbed Pirola, the Omicron subvariant, BA.2.86, was first identified in the UK in August in a person with no recent travel history, suggesting a degree of spread within the community. Since then, the Omicron spin-off has triggered 54 confirmed cases […]

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