Letting go of extra weight to control sleeping sickness

A new study led by Luísa Figueiredo, group leader at the Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal), and published in Nature Microbiology found a new strategy by the host to cope with Trypanosoma brucei infection. Trypanosoma brucei is the parasite that causes sleeping sickness in humans, and nagana in cattle, which remain a public health concern and […]

Continue reading »

High-Dose Aflibercept Sustains Outcomes Over 96 Weeks

The high-dose 8-mg formulation of aflibercept, approved by the US Food and Drug Administration in August, has been shown to sustain improvement in visual acuity as well as retinal anatomy out to 22 months on par with every-other-month treatment with the original 2-mg dose, but with up to 36% fewer injections. Results from the PULSAR randomized clinical trial that compared […]

Continue reading »

New drug molecule restores lost nerve-muscle connections, enhances strength

Reviewed A small molecule previously shown to enhance strength in injured or old laboratory mice does so by restoring lost connections between nerves and muscle fibers, Stanford Medicine researchers have found. The molecule blocks the activity of an aging-associated enzyme, or gerozyme, called 15-PGDH that naturally increases in muscles as they age. The study showed that levels of the gerozyme […]

Continue reading »

Your immune system makes its own antiviral drug—and its likely one of the most ancient

Antiviral drugs are generally considered to be a 20th century invention. But recent research has uncovered an unexpected facet to your immune system: It can synthesize its own antiviral molecules in response to viral infections. My laboratory studies a protein that makes these natural antiviral molecules. Far from a modern human invention, nature evolved cells to make their own “drugs” […]

Continue reading »
1 34 35 36 37 38 1,322