Dual-targeting CAR NK cells can prevent cell dysfunction and tumor escape

Researchers at The University of Texas MD Anderson Cancer Center have developed a new approach to engineering natural killer (NK) cells with a second chimeric antigen receptor (CAR) to act as a logic gate, requiring two signals to eliminate a target cell. In preclinical studies, these next-generation CAR NK cells improved tumor specificity and enhanced anti-tumor activity by overcoming a […]

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Biden Takes Aim at Big Pharma, Republicans in California

IRVINE, Calif. (Reuters) – U.S. President Joe Biden criticized Republicans and drug companies during a stop at a California community college on Friday as he campaigned for fellow Democrats in November’s midterm elections. Biden’s trip includes stops in California on Friday and Oregon on Saturday as the president looks to position his party, the Democrats, as a champion of consumers […]

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Near-infrared spectroscopy can provide a cost-effective way to noninvasively monitor intracranial pressure

An increase in intracranial pressure (ICP) is a dangerous condition that can be caused by brain bleeds, a brain tumor, cerebral edema, traumatic brain injury, and hydrocephalus. ICP monitoring is thus a key aspect of patient care in patients with these disorders. Additionally, ICP measurements are relevant when estimating cerebral perfusion pressure (CPP), an indicator of cerebral autoregulation (CA). CPP […]

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Ibrutinib Now Approved for Children With Chronic GVHD

Ibrutinib (Imbruvica) is now available for use in children aged 1 to 12 years who have chronic graft-vs-host disease (cGVHD), which can develop after stem cell transplantation for treatment of a blood cancer. Specifically, the indication is for pediatric patients with cGVHD who have already been treated with one or more lines of systemic therapy. The manufacturers have also launched a […]

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