Looking at images of people smiling at you extends the antidepressant effects of ketamine

Simple computer-based neurocognitive training—using positive words and pictures designed to boost self-worth—prolongs the antidepressant effects of ketamine in people with treatment-resistant depression, University of Pittsburgh researchers report today in the American Journal of Psychiatry. Results of a double-blind, randomized clinical trial conducted in Pittsburgh suggest that low-cost, automated behavioral interventions during the window of heightened brain plasticity after a single […]

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Do mandatory prescription drug monitoring programs effectively reduce opioid sales?

Prescription drug monitoring programs (PDMPs) have emerged as state‐level interventions intended to curb opioid abuse and over‐prescription. While some states have voluntary PDMPs, others have enacted mandatory or “must-access” programs in which authorized individuals must consult the PDMP before prescribing certain controlled substances. An analysis published in Contemporary Economic Policy reveals that must‐access PDMP implementation does not uniformly reduce prescription […]

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Nicotine and estrogen: Why it's harder for women to quit smoking

Tobacco consumption, especially cigarette smoking, is the leading cause of preventable disease mortality in the United States. Research shows that women tend to have a harder time quitting cigarette consumption than men. A recent study suggests that nicotine’s estrogen-inhibiting activity may be the cause. Swedish scientists observed that a dose of nicotine equal to that found in one cigarette lowered […]

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Disempowered, shut off and less able to afford healthy choices: How financial hardship is bad for Australian health

Australia is facing a cost-of-living crisis. Rising costs of rent, fuel, food and power have increased financial stress for many households. While financial pressures are now being felt by a broader section of society, for many Australians, such pressures are constant. The health costs of such socioeconomic disadvantage are startling. A 2021 report found the most disadvantaged 20% of Australians […]

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A hazard in breastfeeding: Perfluoroalkane acids, a persistent organic pollutant binding to human milk

Biomonitoring for polychlorinated dibenzodioxins and dibenzofurans (PCDD/PCDF) and polychlorinated biphenyls (PCB) has long traditions and was continued with the global monitoring plan (GMP) under the Stockholm Convention on Persistent Organic Pollutants. The aim of the GMP is to apply one framework for sampling and analysis of so-called core matrices to detect temporal and spatial changes of POP concentrations. Due to […]

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Targeting ion channels to manage osteoarthritis pain

Therapeutically targeting ion channels in nociceptor neurons may be a promising strategy to manage osteoarthritis pain, according to a Northwestern Medicine study published in Cell Reports. Paul DeCaen, Ph.D., associate professor of Pharmacology, was senior author of the study. Nociceptor neurons transmit pain signals to the brain using electrical currents generated by voltage-gated sodium channels; when overactive, those channels are […]

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