AAOS: demand for arthroplasty to outpace surgeon capacity

The demand for total joint arthroplasty (TJA) is expected to outpace the orthopedic workforce, according to a study presented at the annual meeting of the American Academy of Orthopaedic Surgeons, held from March 7 to 11 in Las Vegas. Matthew Edward Deren, M.D., from the UMass Memorial Medical Center in Worcester, and colleagues estimated the orthopedic surgeons contributing to the […]

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Study finds non-Hodgkins lymphoma treatment also targets related forms of lymphoma

The search for new therapies to treat a rare type of non-Hodgkins lymphoma has had an unexpected success—identifying a potential molecular target to treat other related forms of lymphoma as well. Professor Richard Ferrero, Dr. Le (Christy) Ying and an international team focused on finding new treatment options for a form of non-Hodgkins lymphoma that develops in the stomach and […]

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MTAP loss in metastatic breast cancer patients: Genomic landscape

A new research paper titled “Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss” has been published in Oncotarget. Homozygous deletion of methylthioadenosine phosphorylase (MTAP) upregulates de novo synthesis of purine (DNSP) and increases the proliferation of neoplastic cells. This increases the sensitivity of breast cancer cells to DNSP inhibitors such as methotrexate, L-alanosine and pemetrexed. […]

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Could modified mRNA therapy help treat Alzheimer's disease?

About 32 million people around the world have Alzheimer’s disease, for which there is currently no cure. Researchers from the Air Force Medical University in China have discovered a potential new therapeutic target for Alzheimer’s disease through the modification of mRNA. These mRNA modifications were able to lower cognitive symptoms of Alzheimer’s disease in a mouse model. About 32 million […]

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