Meta-Analysis Probes Cancer Risk Concern for JAK Inhibitors

MANCHESTER, England — Janus kinase (JAK) inhibitors may be associated with a higher risk for cancer relative to tumor necrosis factor (TNF) inhibitors, according to a meta-analysis reported at the British Society for Rheumatology (BSR) 2023 Annual Meeting. Looking at all phase 2, 3, and 4 trials and long-term extension studies across the indications of rheumatoid arthritis, psoriatic arthritis, psoriasis, […]

Continue reading »

Autistic children exhibit aggression more frequently, study shows

At least half of all autistic children experience some form of aggression, such as hitting, kicking or name-calling, while their parents are tasked with helping them cope and integrate socially. Yet the prevalence and characterization of aggressive behaviors across autistic development are poorly understood. To address this knowledge gap, researchers in the Family and Community Intervention Lab at the University […]

Continue reading »

Novel ATR Inhibitor Shows Promise in Children With Tumors

Combination treatment with the poly ADP-ribose polymerase inhibitor, olaparib, and the novel ataxia telangiectasia–mutated Rad3-related (ATR) inhibitor, ceralasertib, was well tolerated and showed some promise in pediatric patients with tumors with DNA replication stress or DNA repair deficiencies, in a new study. The small phase 1 trial also identified some molecular signatures in responders that may inform future clinical trials. […]

Continue reading »
1 157 158 159 160 161 1,322