Parasite-host "coupling" mechanism could lead to new treatments for malaria

Transmitted through infected mosquitos, the malaria parasite, once in the human bloodstream, synchronously ruptures red blood cells and rapidly infects new red blood cells, beginning the cycle anew. Controlled by an intrinsic clock, this cycle occurs in multiples of 24 hours, depending on the species. Humans infected with malaria parasites exhibit rhythmic fevers and chills every 24, 48 or 72 […]

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High Lp(a) Tied to Higher Coronary Plaque, Progression

MANNHEIM — Patients with high lipoprotein(a) levels not only have an almost twofold higher coronary plaque burden than those with low levels but also a faster rate of plaque progression, an observational imaging study shows. This could explain the greater risk for major adverse cardiovascular events seen in patients with high lipoprotein(a) [Lp(a)] levels, suggests the research, presented at the […]

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Multiple sclerosis discovery IDs key factor that shapes your risk

University of Virginia School of Medicine scientists have discovered a key determinant of our risk for multiple sclerosis (MS), advancing efforts to prevent and better treat the disease. Researchers led by Mariano Garcia-Blanco, MD, Ph.D., chair of UVA’s Department of Microbiology, Immunology and Cancer Biology, identified a series of processes in our cells that suppresses our risk for developing multiple […]

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Brain tumors are cognitive parasites—how brain cancer hijacks neural circuits and causes cognitive decline

Researchers have long known that brain tumors, specifically a type of tumor called a glioma, can affect a person’s cognitive and physical function. Patients with glioblastoma, the most fatal type of brain tumor in adults, experience an especially drastic decline in quality of life. Glioblastomas are thought to impair normal brain functions by compressing and causing healthy tissue to swell, […]

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MS in Black People More Common Than Previously Thought

TOPLINE: United States residents continue to have the highest prevalence of multiple sclerosis (MS). However, new data show the disease is becoming more racially diverse, with a higher prevalence in Black people than previously thought. METHODOLOGY: Researchers applied a validated case-finding algorithm to health claims datasets from private, military, and public (Medicaid and Medicare) insurance programs They calculated the cumulative […]

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FDA approves lynparza for BRCA-mutated metastatic castration-resistant prostate cancer

The U.S. Food and Drug Administration approved Lynparza (olaparib) with abiraterone and prednisone (or prednisolone) for adult patients with deleterious or suspected deleterious BRCA-mutated, metastatic, castration-resistant prostate cancer (mCRPC). The approval was based on findings from the PROpel trial in which 796 patients with mCRPC were randomly assigned (1:1) to receive either Lynparza with abiraterone or placebo with abiraterone and […]

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