Reviewed Essential features of the cortex, an important part of the human brain and its development, are more accurately captured in organoids generated by researchers of the Princess Máxima Center for pediatric oncology and the Hubrecht Institute. The scientists developed mini-organs with features like cell organization, stem cell expansion and cell identity that more closely mimic the real-life situation. These […]

A large proportion of patients who start taking ADHD medication, especially young adults, stop within the first year. However, people who use ADHD medicine for a long time and in higher-than-average doses seem to have a higher risk of some cardiovascular diseases. This is according to two new studies led by researchers from Karolinska Institutet and published in The Lancet […]

Scientists at St. Jude Children’s Research Hospital have comprehensively identified genes directly regulated by a protein associated with high-risk pediatric leukemias. High-risk leukemias, particularly MLL-rearranged (MLL-r) leukemia, often overexpress the homeodomain transcription factor HOXA9 protein, which cannot currently be targeted with drugs. This study provides a foundation for revealing the HOXA9 regulation network and finding novel drug targets downstream of […]

Exonate Ltd. (the Company), an mRNA therapy company focused on treatments for diabetic complications, today announced its lead ophthalmology asset, EXN407, has achieved its prespecified endpoints in a phase Ib/IIa study. During the trial EXN407 met all safety and pharmacokinetic parameters and displayed encouraging signals of biological activity. Exonate has now regained full rights to its complete portfolio of ophthalmology […]

Australia will ban imports of disposable vapes from January 1, the government said Tuesday, slamming the devices as recreational products addicting children. The block on single-use vapes is aimed at reversing a “disturbing” increase in vaping among young people, Health Minister Mark Butler said. Australia first revealed the import ban in May but had not given a start date until […]

In a recent review published in the journal Nutrients, researchers evaluated the evidence on the effects of two omega-3 polyunsaturated fatty acids (n-3 PUFAs), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the health of athletes. They also discussed the risks and benefits associated with DHA and EPA supplementation in this population. ​​​​​​​Study: Athletes Can Benefit from Increased Intake […]

Former smokers avoid more than half of the excess cardiovascular, cancer, and respiratory mortality associated with current smoking within the first decade after quitting, according to a research letter published online Nov. 27 in JAMA Internal Medicine. Blake Thomson, D.Phil., and Farhad Islami, M.D., Ph.D., from the American Cancer Society in Atlanta, examined the association between years since quitting smoking […]

A study led by Guadalupe Sabio and José Jalife at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid has identified a new signaling mechanism implicated in the development of ventricular fibrillation, a type of arrhythmia, or irregular heartbeat. The study findings, published in the journal Nature Cardiovascular Research, offer promise of future treatment options for this life-threatening condition. Ventricular […]

OpenAI’s GPT-4 correctly diagnosed 52.7% of complex challenge cases, compared to 36% of medical journal readers, and outperformed 99.98% of simulated human readers, according to a study published by the New England Journal of Medicine. The evaluation, conducted by researchers in Denmark, utilized GPT-4 to find diagnoses pertaining to 38 complex clinical case challenges with text information published online between January […]

Pregnancy and motherhood lead to brain remodeling. A research team at the University of Basel has now discovered through experiments with mice that distinct pools of stem cells in the adult brain are turned on during pregnancy. They give rise to specific types of olfactory bulb neurons, the team reports in Science. In the animal kingdom, recognizing their offspring by […]