The “circuit” metaphor of the brain is as indisputable as it is familiar: Neurons forge direct physical connections to create functional networks, for instance to store memories or produce thoughts. But the metaphor is also incomplete. What drives these circuits and networks to come together? New evidence suggests that at least some of this coordination comes from electric fields. The […]

Last month, The Lancet published the results of a phase 3 trial that assessed the use of a highly selective, potent oral vascular endothelial growth factor receptor (VEGFR) inhibitor for patients with refractory metastatic colorectal cancer (CRC). The trial, dubbed FRESCO-2, found that use of fruquintinib “resulted in a significant and clinically meaningful benefit in overall survival compared with placebo […]

A Ludwig Cancer Research study has discovered that the presence of relatively high numbers of immune cells known as monocytes in tumors is linked to better outcomes in esophageal cancer patients treated with a combination of chemotherapy and immunotherapy, or immunochemotherapy. Esophageal cancer is the sixth leading cause of cancer mortality worldwide, and the incidence of esophageal adenocarcinoma has been […]

The summer of 2022 was the hottest summer ever recorded in Europe and was characterized by an intense series of record-breaking heat waves, droughts and forest fires. While Eurostat, the European statistical office, already reported unusually high excess mortality for those dates, until now the fraction of mortality attributable to heat had not been quantified. This is precisely what has […]

A study published in the Foods Journal finds that some preharvest and postharvest factors may influence the quality of blueberries. However, blueberries' phenolic content and antioxidant properties, the phenolic content and antioxidant property of blueberries remain within the expected range at the time of purchase.    Study: Are the Blueberries We Buy Good Quality? Comparative Study of Berries Purchased from Different Outlets. […]

At the start of the coronavirus disease 2019 (COVID-19) pandemic, analog techniques like nasopharyngeal swab specimens for polymerase chain reaction (PCR) testing were prominent. The widespread use of nonpharmaceutical interventions (NPIs) such as facemasks and social distancing was reminiscent of the influenza outbreak in 1918. Despite the prevalence of smartphones throughout the world, scientific studies on digital technology, especially those […]

Penis enlargement gone wrong: Eye-watering stories of men left suicidal and in agony following ‘Frankenstein’ surgery that left them misshapen The average flaccid penis size for an adult is usually between three to four inches Victim of a botched penis procedure? Email [email protected]  Matt was just one of dozens of men unhappy with his penis and who sought genital-enhancement surgery […]

I’ll never forget the day I woke up with the worst headache of my life. It was pounding. I’d been out the night before with the girls, but I knew it wasn’t a hangover – I’d only had two pints.  After another hour’s sleep and still not feeling any better, I hoped a shower might help. I was about to […]

Lord Black of Brentwood is joining our call for all over-50s to be given access to a bone specialist. The Sunday Express has teamed up with The Royal Osteoporosis Society to campaign for £30million annual funding to stop the standard of treatment being a “postcode lottery”. In an exclusive interview, Lord Black said that because the condition often remains under the […]

Reviewers’ Notes A new research paper was published in Genes & Cancer on June 28, 2023, entitled, "A novel t (5; 17) (q35; q21) associated with t (8; 21) (q22; q22) in a patient with acute myeloid leukemia: case report and review of literature." The t (8; 21) (q22; q22) with the resulting RUNX1- RUNX1T1 rearrangement is one of the […]